MSigDB v6.0 (Apr 2017)

Change of License Terms#

MSigDB v6.0 is now available under a Creative Commons license, with additional terms for some sub-collections of gene sets. Note however that earlier versions of MSigDB are still under the older license terms. See the License Term page for details.

Updates to C2:CGP — Curated Gene Sets#

Changes to C3 — Motif Gene Sets#

We updated the brief and full descriptions for the C3 gene sets. We also changed gene set names to eliminate problem characters:

For example:

Changes to C5 Collection — Gene Ontology#

Grouping sets by gene ontology (GO) terms can potentially produce identical sets for different GO terms. We have a procedure in place to detect and resolve these cases. Unfortunately, in the previous release of the database, several identical sets slipped through. Alerted by astute users of MSigDB (thank you!), we improved the procedure and were able to identify and eliminate 249 duplicate sets.

Other Changes#

The Downloads page provides GMT files with gene sets composed of HUGO gene symbols and Entrez gene symbols. GMT files with sets composed of original gene identifiers are no longer provided. This information is available in the XML file of the database and on the individual gene set pages online.